The only T2D therapy approved by the FDA to reduce the risk of end-stage kidney disease, doubling of serum creatinine, cardiovascular death, and hospitalization for heart failure in adults who have T2D and diabetic nephropathy with albuminuria >300 mg/day1

In adults with DKD* and T2D,

INVOKANA® 100 mg is the only SGLT2i proven to deliver all of the following:

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Reduced progression of DKD1

30% RRR in primary composite outcome of end-stage kidney disease, doubling of serum creatinine, and renal or CV death.5

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Reduced risk of hospitalization for heart failure1

39% RRR§ in hospitalization for heart failure.6

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Proven safety profile in patients with an eGFR of 30 to <901

  • Similar overall AEs with INVOKANA® vs placebo (35.1 vs 37.9 per 100 patient-years), except for DKA and male GMI. No imbalance in fracture or amputation. Hypotension incidence was 2.8% vs 1.5%, respectively1,5
  • INVOKANA® 100 mg can be initiated in patients with an eGFR as low as 30.* Patients already on INVOKANA® whose eGFR declines below 30* can continue on the 100-mg dose unless dialysis is initiated1
  • INVOKANA® is contraindicated in patients in dialysis.

eGFR is measured in mL/min/1.73 m 2.
*With albuminuria >300 mg/day.
End-stage kidney disease was defined as dialysis for ≥30 days, kidney transplantation, or an eGFR <15 mL/min/1.73 m 2 sustained for ≥30 days.
There were not enough events to evaluate the risk of renal death (placebo, n=5; INVOKANA®, n=2). INVOKANA® is not indicated to reduce the risk of renal death.
§RRR was calculated using the following formula: 100 x (1–HR).

AEs=adverse events; CV=cardiovascular; DKA=diabetic ketoacidosis; DKD=diabetic kidney disease; GMI=genital mycotic infection; RRR=relative risk reduction; SGLT2i=sodium-glucose co-transporter 2 inhibitor; T2D=type 2 diabetes.

References: 1. INVOKANA® [prescribing information]. Titusville, NJ: Janssen Pharmaceuticals, Inc. 2. Jardiance® [prescribing information]. Ridgefield, CT: Boehringer lngelheim Pharmaceuticals, Inc. 3. Farxiga® [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP. 4. Steglatro TM [prescribing information]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. 5. Perkovic V, Jardine MJ, Neal B, et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 2019;380(24):2295-2306. Supplementary appendix available at: doi:10.1056/NEJMoa1811744. 6. Mahaffey KW, Jardine MJ, Bompoint S, et al. Canagliflozin and cardiovascular and renal outcomes in type 2 diabetes mellitus and chronic kidney disease in primary and secondary cardiovascular prevention groups. Circulation. 2019;140(9):739-750.